Monday, April 29, 2024

Design Therapeutics Announces Positive Preclinical Data

design therapeutics

In addition to its lead GeneTAC™ small molecule, DT-216, in development for patients with Friedreich ataxia, the company is advancing programs in Fuchs endothelial corneal dystrophy, Huntington’s disease and myotonic dystrophy type-1. We are developing a portfolio of GeneTAC™ product candidates designed to address genetic diseases driven by inherited nucleotide repeat expansions. GeneTAC™ molecules are designed to be a novel class of disease-modifying small molecule therapeutic candidates that can either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. The development of drugs to treat genetic disease has largely focused on novel complex modalities such as gene therapy or gene editing that have proven to be challenging to develop. Until recently, scientists had not succeeded in using small molecules for selective, targeted transcription modulation. Through our GeneTAC™ platform, we have designed small molecules that effectively target and dial up or down the expression of specific genes, with one of our lead compounds having entered the clinic in 2022.

A New Approach to Treating Genetic Disease

There is currently no effective therapeutic intervention that addresses the root cause of the disease. Corneal transplantation, including various modalities of keratoplasty, is the only treatment option to correct advanced FECD. In August 2023, we reported data from the MAD Phase 1 clinical trial showing that DT-216 was generally well-tolerated and exhibited the ability to overcome the FXN transcription impairment that causes FA. We have developed a new drug product candidate, DT-216P2, for patients with FA that demonstrated an improved pharmacokinetic profile and a favorable injection site safety profile in nonclinical studies. Xaira is building significant AI research capabilities spanning fundamental computational methods development and their application to biological discovery, the design of drug-like matter, and clinical development.

Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 2022 Financial Results

Affected individuals have reduced life expectancy, with many premature deaths caused by complications of cardiomyopathy at about the end of the fourth decade of life. The estimated prevalence of FA is 1 in 40,000–50,000, affecting more than 5,000 individuals living in the United States and more than 20,000 in Europe. Our team consists of recognized global leaders in the field of DNA-targeted small molecules, transcription modulation, medicinal chemistry, translation, and development into clinical applications. "We have reached the point where AI finally allows us to see biology in new ways, and translate those discoveries to better treatments for disease," said Robert Nelsen, Managing Director and Co-Founder of ARCH Venture Partners. "This creates an enormous opportunity for us to rethink drug discovery entirely. For this reason, Xaira is the largest initial funding commitment in ARCH history."

MarketBeat Products

These HD GeneTAC™ small molecules are designed to address the root cause of HD by selectively reducing the toxic mtHTT gene product and distribute to the whole brain when administered systemically. The research collaboration was established to design and test agonistic antibodies targeting tumor necrosis factor receptor type II (TNFR2), a novel, biologically-validated disease target implicated in a wide range of autoimmune diseases that has been difficult to drug with conventional medicines. “At Design, our vision is to develop a portfolio of first or best-in-class small molecules capable of treating a host of degenerative diseases by working with a patient’s natural genome to restore cellular health.

From the University of Pennsylvania School of Medicine and an MBA (Mayer Scholar) from the Wharton School of the University of Pennsylvania. SAN FRANCISCO, April 23, (BUSINESS WIRE)--Xaira Therapeutics launched today on a mission to help re-engineer the way we discover and develop medicines through the end-to-end application of emerging AI technologies. A star-stud­ded mix of ven­ture cap­i­tal­ists and sci­en­tists, backed by more than a bil­lion dol­lars, is launch­ing an am­bi­tious biotech that aims to rein­vent drug R&D us­ing ar­ti­fi­cial in­tel­li­gence, the group ex­clu­sive­ly told End­points News. (Steve) MayoBren Professor of Biology and Chemistry; Merkin Institute ProfessorThe focus of the lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. Click the link below and we'll send you MarketBeat's list of ten stocks that will drive in any economic environment. While Design Therapeutics currently has a "Hold" rating among analysts, top-rated analysts believe these five stocks are better buys.

BML Capital Management LLC Invests $2.73 Million in Design Therapeutics, Inc. (NASDAQ:DSGN)

The variability of results observed with this current method substantially limited the utility of FXN protein measurements to assess DT-216 pharmacology. Myotonic dystrophy (DM1) is a monogenic, autosomal dominant, progressive neuromuscular disease that affects skeletal muscle, heart, brain and other organs. The cardinal features include muscle weakness, myotonia (slow muscle relaxation) and early cataracts. In addition, affected individuals often experience cardiac arrhythmias and changes in neuropsychological function.

Fuchs Endothelial Corneal Dystrophy Program

Aseem Z. Ansari, Ph.D. is a co-founder and scientific advisor of Design Therapeutics. Dr. Ansari pioneered the development of synthetic transcription factors, and over the past 25 years, performed the foundational research that led to Design Therapeutics. Dr. Ansari is the chair of the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital. He received his Ph.D. in chemical biology from Northwestern University and was a postdoctoral fellow at Harvard and MIT. Dr. Ansari’s research has produced important new insights into cellular processes that govern gene expression and has developed novel small molecules that can influence gene regulatory networks and cell fate.

Design Therapeutics Company Profile

Prior to Design, Ms. Burgess served as the senior vice president of finance at Otonomy, Inc., Corporate Controller at Apricus Biosciences, and a consultant to several other biopharmaceutical companies. Ms. Burgess is a licensed CPA and completed her MBA at San Diego State University. This collective knowledge and expertise serve as the engine for our innovative approach and make us uniquely equipped to harness the power of our GeneTAC™ small molecules for the treatment of genetic disease. DT-216 Program Next StepsThe initial results from Design’s Phase 1 multiple ascending dose trial underscore the promise of DT-216 as a potential disease-modifying treatment for FA. FXN protein measurements in skeletal muscle had substantial overlap between FA patients and carriers and showed high intra-individual variability. More than half of FA patients had 25% or more variation in FXN protein levels between visits, with intra-individual coefficient of variation of 69%.

Bris­tol My­ers out­lines ‘about 12’ pipeline cuts as it ex­e­cutes ma­jor cut­backs

Corton Capital Inc. now owns 27,134 shares of the company's stock worth $64,000 after purchasing an additional 9,811 shares in the last quarter. Algert Global LLC boosted its position in shares of Design Therapeutics by 83.3% during the third quarter. Algert Global LLC now owns 35,620 shares of the company's stock worth $84,000 after acquiring an additional 16,190 shares during the last quarter.

design therapeutics

About Design TherapeuticsDesign Therapeutics is a clinical-stage biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules. The company’s GeneTAC™ molecules are designed to either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. In addition to its lead GeneTAC™ small molecule, DT-216, in development for patients with Friedreich ataxia, the company is advancing programs in Fuchs endothelial corneal dystrophy and myotonic dystrophy type-1. Discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions are also underway, including for fragile X syndrome, spinocerebellar ataxias, Huntington disease, spinobulbar muscular atrophy, and C9orf72-amyotrophic lateral sclerosis/frontotemporal dementia. Design’s lead program is focused on the treatment of Friedreich ataxia, followed by a program in myotonic dystrophy type-1 and discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions. About Design TherapeuticsDesign Therapeutics is a biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules.

GeneTAC™ molecules are also designed to work with the natural genome without altering a patient’s DNA. Dr. Louise Rodino-Klapac discusses the science of limb-girdle muscular dystrophies (LGMDs) and how our gene therapy engine will help engineer potential therapies for this group of inherited neuromuscular diseases. Royal Bank of Canada restated a "sector perform" rating and set a $4.00 target price on shares of Design Therapeutics in a research report on Wednesday, March 20th. Wedbush restated a "neutral" rating and set a $5.00 target price on shares of Design Therapeutics in a research report on Wednesday, March 20th. Seven analysts have rated the stock with a hold rating, According to MarketBeat.com, the stock currently has a consensus rating of "Hold" and a consensus price target of $5.50.

Design has since shown that an improved formulation had favorable injection site tolerability following multiple intravenous administrations and enabled dosing to increase tissue exposure. Our FECD program leverages our expertise in designing GeneTAC™ small molecules that address the underlying cause of the disease. FECD GeneTAC™ molecules have shown to markedly reduce nuclear foci and improve spliceopathy in FECD CEC cultures derived from donors who underwent corneal transplant.In December 2022, DT-168 was declared a drug candidate for FECD. DT-168 is a GeneTAC™ small molecule designed to target the CTG repeats in the TCF4 gene and selectively block transcription of the expansion-containing allele. He has deep experience developing innovative therapies across multiple diseases and therapeutic modalities through all phases of drug development. Prior to joining Design, Dr. Kim was Chief Medical Officer of Avidity Biosciences.

Most recently, Dr. Lappe served as executive chairman of the board of directors for Mirati Therapeutics (MRTX), a role he had served at until he resigned in February 2019, after becoming a member of the board in June 2012 and chairman of the board in July 2013. Previously, Dr. Lappe was group senior vice president, Pfizer Worldwide Research and Development and chief scientific officer for CovX in San Diego. Dr. Lappe has also served as vice president for cardiovascular and metabolic diseases at Pharmacia where he was also site leader for Pharmacia in St. Louis. Prior to joining Pharmacia, he held positions with Wyeth, Rorer Central Research, CIBA Geigy and Searle Pharmaceuticals. "In my previous roles, I witnessed an earlier generation of technologies fundamentally change drug discovery, delivering new medicines that alleviate the burden of disease for many patients," said Dr. Marc Tessier-Lavigne, CEO.

Design Therapeutics, Inc. (DSGN) Upgraded to Buy: Here's What You Should Know - Yahoo Finance

Design Therapeutics, Inc. (DSGN) Upgraded to Buy: Here's What You Should Know.

Posted: Mon, 18 Dec 2023 08:00:00 GMT [source]

Prior to Avidity, he served as Clinical Research Head, Vice President of Clinical Development and Chair of the Clinical Trial Review Board at Alnylam Pharmaceuticals. Before Alnylam, he served in roles of increasing responsibility in global development at MyoKardia, Inc. and Amgen. He contributed substantially to the development and/or approvals of Givlaari® (givosiran), Amvuttra® (vutrisiran), Leqvio® (inclisiran), Camzyos® (mavacamten), Corlanor® (ivabradine), and Repatha® (evolocumab). "In starting Xaira, we have brought together incredible multidisciplinary talent and capabilities at the right time to reimagine our entire approach, from drug discovery to clinical development." These data, supplemented by a growing body of data from the company’s GeneTAC program for Friedrich ataxia, support the continued advancement of the DM1 program and rationale to evaluate the utility of the GeneTAC approach in multiple additional nucleotide repeat expansion diseases. Clinical results from our lead GeneTAC™ small molecule (DT-216) for Friedreich ataxia have shown that our GeneTAC™ approach can modulate target gene expression in patients after a single dose, demonstrating the mechanism and promise of this platform.

at No comments:

The 5 Best Trundle Beds of 2023

house bed

Featuring mid-century modern elements like a dowelled headboard and tapered legs, this wooden bed frame from West Elm combines vintage style with modern design for a streamlined look that's totally on-trend. We appreciate that the bed frame uses sustainably harvested wood and is produced in a Fair Trade Certified facility. This model has a 14-inch rise for lots of storage in a small space, and the brand offers an 18-inch design for even more room. As Carroll tells us, “We humans spend about one-third of our lives in bed. Our bodies need sleep to recover from the day, rebuild cells, detoxify, and rest.” With this in mind, it’s imperative to make sure that your bed frame is comfortable. Comfort can mean a few different things, but mainly, you’ll want a bed frame that allows the mattress you’ve spent good money on to do its job.

Twin size house bed PDF plan, Montessori bed plan, DIY (do-it-yourself) project, House bed frame plan...

Bring Scandinavian style into your home with this cute, minimalist house bed from South Shore. Elsewhere, at 21 Church Street in Randwick a four-bedroom semi, devoid of furniture and virtually staged for the photos, sold bang on reserve for $2.5 million. The six-bedroom, five-bathroom family estate at 23 Westbrook Avenue had multiple living quarters, including a bedroom for the family dog, and drew a crowd of 200 at auction on the weekend. Our Reviews Team is committed to delivering honest, objective, and independent reviews on home products and services. Amanda (she/her) researches and reports on products in the Good Housekeeping Institute's Textiles, Paper & Apparel Lab, ranging from clothing and accessories to home furnishings. She holds undergraduate degrees in apparel merchandising and product development and advertising and marketing communications, as well as a master of science degree in consumer sciences from The Ohio State University.

Zipadee Kids Recalls Convertible House Bed Frames and Montessori Floor Beds Due to Entrapment and Strangulation ... - Consumer Product Safety Commission

Zipadee Kids Recalls Convertible House Bed Frames and Montessori Floor Beds Due to Entrapment and Strangulation ....

Posted: Thu, 17 Aug 2023 07:00:00 GMT [source]

Pros and Cons of the Novogratz Her Majesty Upholstered Trundle

house bed

It’s not just good for the occasional sleepover, it is comfortable enough for a long visit if you have friends or relatives staying over. If it will benefit you and your guests to have enhanced flexibility, consider if a daybed or futon bed might make more sense than a traditional bed. In a small apartment, this can save you the space of a separate couch without losing comfortable seating options. A daybed can also work well for apartment life, though they are especially popular for guest rooms that double as home offices. Adults can sleep on a trundle bed, just make sure you pick out of a frame with well-regarded durability. A cheaply-made frame may hold up fine under the weight of a toddler or small child, whereas your adult back will feel the achy consequences of a flimsy frame.

Brooklyn Open Houses: A Bed Stuy Brownstone - Brownstoner

Brooklyn Open Houses: A Bed Stuy Brownstone.

Posted: Fri, 26 Apr 2024 16:01:55 GMT [source]

The 5 Best Trundle Beds

However, it’s important to note that you get what you pay for with a brand like this, as it offers white glove delivery as well as beds that are made with highly durable materials. With 59 bed frames to choose from on the company’s site, you won’t be shortchanged when seeking out something to fit your needs. We really love the Camerano Eggshell Upholstered Queen Bed for its unique-looking angled head and footboards. Plus, the upholstery fabric is easy to clean and stain-resistant in case you accidentally spill something on it. Our pick for best guest room trundle stood out to us among the sea of classic, diamond tufted upholstery. Instead, the Mr. Kate Daphne boasts a bold, striped, mid-century modern style upholstered frame.

Similarly, if you are going with a midcentury look in your space, consider a bed frame like Article’s Lenia Panel White Oak Queen Bed. With tapered legs and a no-frills silhouette, this bed frame is a wonderful addition to any mid-century modern bedroom. One of the most individual aspects of a bed frame is going to be its design. For continuity purposes, make sure that your bed frame matches the style of the rest of the room. If you have a more classical dresser, you’ll want a more classical bed frame.

house bed

Because the popular frame is in such high demand, it may take several weeks to ship, depending on your location and the color you select. Thanks to Thuma's thoughtful bed frame design, you don't have to worry about tricky assembly. The bed frame can be built without any tools and requires just two bolts to be twisted into place. On Anthropologie’s website, there are currently 78 beds, bed frames, and headboards, all ranging in style from bohemian design to more classically ornate to midcentury modern.

West Elm also offers tons of matching furniture, including nightstands and dressers. One of our GH Lab experts owns several pieces from this line and says the furniture "looks luxurious and has held up well" over time. Online reviewers love that this simple style has a little storage space underneath, although the bed sits very close to the ground, which can make getting in and out of bed difficult. There are three types of wood to choose from and two colors of hardware to match your space. Lots of add-ons can attach directly to the frame, such as under-bed storage drawers, nightstands and a headboard (but these cost extra). In the Good Housekeeping Institute Textiles Lab, we test bedding of all kinds and evaluate bedroom essentials based on feedback from our survey panelists, a group comprised of thousands of GH readers and GH+ members.

Pros and Cons of the Avocado Kids Trundle Frame

A sturdy metal frame is another solid choice, but may be less comfortable to get cozy on for sleeping compared to wooden upholstered frames. At the Good Housekeeping Institute, we evaluate bedroom essentials of all kinds, from mattresses to pillows to sheets to bed frames. For this article, we first researched best-selling bed frames from popular brands, considering features like material, style, sizing, assembly and additional accessories.

Montessori Toddler House Bed with Rails Plan - DIY Full Size Wooden Floor House Bed Frame Plan For Kids - Download PDF

Its black, twin-size house bed is made of solid metal tubes and has a mattress platform that sits directly on the floor. If you don’t want your child’s mattress to sit directly on the floor you will also need a box spring. You may want to consider a less high-end trundle for a guest bed that serves a more limited role, rather than as the main bed.

In particular, we love the bestseller Malm for its adjustable bed sides that allow you to adjust for mattress thickness, as well as its high headboard for late-night reading. Plus, priced at under $300 for a queen, it's hard to beat the Malm’s overall value. While its two founders, Niraj Shah and Steve Conine, began working together in the early 2000s, Wayfair, as we know it online, didn’t come to be until 2011. Since then, the online giant has become a go-to shopping destination for millions of home-related products, ranging from bathroom accessories and door hardware to, you guessed it, beds. Instead of the waste that comes attached to outgrowing a bed, Floyd’s bed frame can actually be adjusted in size by adding panels (great if you’re unsure which bed size is right for you). But because of its ability to offer modern flair to spaces at more affordable prices, it could more accurately be described as the brand’s cool younger sister.

The comfort of a trundle bed will depend on a few factors, some of which are within the scope of the frame, like the headboard. As far as the mattress that will be rolled out on the actual trundle part of the frame, your options are limited to thinner mattresses. Thinner mattresses can start out uber-comfortable, but their lack of long term durability can compromise your comfort down the line if they are judiciously replaced. Our testers loved that everything required for setup came in a compact box, and they found the bed frame easy to assemble with the tools and instructions provided by the brand. They also appreciated the Velcro-like material that keeps the bed's wooden support slates securely in place.

The fence runs around the outer perimeter of the bed frame, except for an 18-inch gap that is left open. This space allows your child to get into and out of bed without having to climb over the rails. In addition to the fence, there is also a chimney-shaped frame that sits on top of the roofline. The impressive home had a price guide of $8 million and was rejuvenated with extensive renovations in 2018. The vendors converted the old office into a dog bedroom for their Tibetan mastiff, that was “looked after like a prince”, with a custom-built shower space.

To help you in your search, we researched dozens of brands, considering their style offerings, price points, and durability needs. In addition to speaking with Carroll, we also consulted with interior designers Tina Ramchandani and Micky Klein for tips on using a bed frame to optimize the design of your bedroom. If your child is currently in a crib or toddler bed, you can find house beds that will fit their existing mattress.

Amanda Constantine joined the Good Housekeeping Institute in 2022 as a home and apparel reviews analyst in the Textiles, Paper & Apparel Lab. She has researched and tested home goods such as blackout curtains, mattresses and recliners, and used her categorical expertise while updating this article. She also received input and product feedback from other editors and product analysts at Good Housekeeping. Whether you want a stylish headboard or lots of storage space (or both), these are the beds for you. While it also offers a sleek headboard option, the pillow board is made with CertiPUR-US certified foam for supreme comfort, with a sleek, low-profile design.

Choose from gray, white or black lightweight particleboard to match your space. IKEA offers additional shelving, wardrobes and more in the Brimnes collection for a coordinating bedroom set. Although it may be difficult to assemble, online reviewers agree that there is ample storage space and that the drawers can hold lots of clothing and linens. One reviewer commented, "This bed has the BIGGEST storage draws I've ever seen... perfect for hiding toys to keep a room clean." The GH analyst also loves how much under-bed clearance (a whopping 13 inches) it offers.

at No comments:

Sunday, April 28, 2024

Biopharmaceutical Company for Rare Diseases

design therapeutics

Design Therapeutics, Inc. has a 12 month low of $1.94 and a 12 month high of $8.47. The firm's fifty day simple moving average is $3.25 and its 200-day simple moving average is $2.66. Mustapha joins Design from Pillsbury Winthrop Shaw Pittman LLP, where he served as special counsel in the Corporate & Securities – Technology practice group, representing start-up, emerging, and public companies in a wide range of transactions and matters throughout the business life cycle. Prior to Pillsbury Winthrop Shaw Pittman LLP, he served as senior corporate attorney at Genoptix, a Novartis Company, where he advised the company on a variety of legal matters and played an active role with the acquisition of Genoptix by Novartis and other strategic transactions.

Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 2022 Financial Results

From Harvard Medical School where he was a Gerald S. Foster Scholar, an MBA from Stanford’s Graduate School of Business, and a BS with Honors in Biology from Stanford University. Previously, Dr. George worked in management consulting (Bain & Co.) and investment banking (Goldman Sachs). Dr. George is a co-founder and board member of Nkarta and currently serves on the board of CRISPR Therapeutics (CRSP). Dr. George previously served of the boards of Turning Point Therapeutics (TPTX), Principia Biopharma (PRNB), Progyny (PGNY), HTG Molecular (HTGM) and Genocea Biosciences (GNCA). In neuroscience from Johns Hopkins University, where he graduated Phi Beta Kappa.

How Our GeneTAC™ Molecules Work

Increasing lines of evidence also suggest that loss of normal HTT function contributes to the HD pathology. Thus, we believe an allele-selective therapeutic that can dial down mtHTT expression and reduce mtHTT mRNA and protein while preserving wtHTT expression represents a highly desirable therapeutic profile. Through our GeneTAC™ (Gene Targeted Chimera) platform, we are leveraging our deep understanding of gene regulation and the tried-and-true power of small molecules to develop therapeutic candidates that target the underlying cause of genetic disorders. The company’s board comprises eminent scientists and seasoned company builders, as well as executives from successful drug development enterprises and technology companies.

Up­dat­ed: FDA ap­proves Pfiz­er’s he­mo­phil­ia B gene ther­a­py, with $3.5M price tag

Stella Xu, Ph.D. is managing director of Quan Capital, a life science venture fund with deep expertise and broad experiences in cross-border value creation and global investments. Prior to Quan, Dr. Xu was corporate vice president/site head of Roche R&D Center China and a core member of the global management team of Roche’s Immunology, Inflammation & Infectious Diseases Division. From 2012 to 2017, she led the fully integrated team of approximately 200 scientists to deliver an innovative pipeline from discovery to global clinical development. She also had extensive global business development experience with Roche Partnering.

Leadership Team

BIOVIA Generative Therapeutics Design - Dassault Systèmes

BIOVIA Generative Therapeutics Design.

Posted: Thu, 05 Oct 2023 22:51:57 GMT [source]

We have shown that GeneTAC™ small molecules can directly distribute into multiple tissues and can be formulated for different routes of administration. Similar to other small molecules, GeneTAC™ molecules can be tailored to achieve a desired effect without requiring cutting, editing or inserting exogenous genes, thereby avoiding the challenges and risks of developing a therapeutic that causes a permanent genetic change. Design is leveraging its proprietary GeneTAC (gene targeted chimera) platform to develop therapeutic candidates for inherited diseases driven by nucleotide repeat expansions, such as DM1. Transcription of the mutant DMPK gene forms pre-mRNAs with large CUG hairpin loops that trap splicing proteins in the nucleus. Specifically, the mutant DMPK pre-mRNAs trap a critical CUG-binding protein called muscle blind-like protein 1 (MBNL1), which leads to the formation of toxic nuclear foci.

Learn more about what goes into manufacturing gene therapies and Sarepta’s approach to meeting the challenges inherent in making these transformative therapies a reality for patients with rare diseases. Following successful preclinical in vitro and in vivo studies, Nektar decided to exercise the license option and has been advancing the program through IND enabling studies since late December, 2023. If the NKTR-0165 candidate proceeds through clinical development, Biolojic Design is entitled to development milestones and sales royalties. Other hedge funds and other institutional investors have also recently modified their holdings of the company.

Shares of Design Therapeutics stock traded down $0.01 during trading on Wednesday, hitting $3.65. The stock had a trading volume of 192,880 shares, compared to its average volume of 262,557. The stock has a market cap of $206.19 million, a PE ratio of -3.04 and a beta of 1.82.

A New Approach to Treating Genetic Disease

design therapeutics

In addition, Dr. Shah serves as chairperson of the board at ARS Pharmaceuticals. Until February of 2020, he served as chairperson of Synthorx, Inc., a biotechnology company developing innovative protein therapeutics for cancer and autoimmune disorders that was acquired by Sanofi for $2.5 billion. Before that, Dr. Shah was president and chief executive officer of Auspex Pharmaceuticals, a biopharmaceutical company focused on the development and commercialization of novel medicines for people with movement disorders, including AUSTEDO® (deutetrabenazine).

Design therapeutics director buys shares worth over $99k - Investing.com

Design therapeutics director buys shares worth over $99k.

Posted: Mon, 25 Mar 2024 07:00:00 GMT [source]

Bris­tol My­ers out­lines ‘about 12’ pipeline cuts as it ex­e­cutes ma­jor cut­backs

Huntington’s disease (HD) is a dominantly inherited, monogenic neurodegenerative disease characterized by progressive movement, cognitive and psychiatric disorders. Symptoms of HD typically appear between the ages of 30 and 50 and worsen over the next 10 to 25 years, leading to death in approximately 15 years, on average, after the onset of motor signs and symptoms. People with advanced HD need full-time care to help with their day-to-day activities and ultimately succumb to pneumonia, heart failure or other complications. It is estimated that approximately 40,000 people in the United States have symptomatic HD, and more than 200,000 people in the United States are at risk of developing HD.

Low FXN expression results in mitochondrial and cellular dysfunction and leads to all FA disease manifestations. DT-216 is a GeneTAC™ small molecule designed to specifically target the GAA repeat expansion mutation, unblock the transcriptional machinery, and restore the production of functional, natural FXN mRNA. Our HD program is based on GeneTAC™ molecules consisting of a DNA-targeting moiety designed to target to the CAG repeats in the Exon 1 region of the HTT gene, linked to a ligand moiety that is designed to dial down the transcription of the mutant allele without disrupting the normal HTT expression.

As a consequence, fluid accumulates in the cornea (corneal edema), causing reduced visual acuity, reduced contrast sensitivity, glare, and eventual corneal blindness. Design was founded with a vision of restoring health to patients with genetic disorders by harnessing their body’s own biology. And Nelly Soux Professor of MicrobiologyThrough genomics, microbiology, immunology, neurobiology and animal models, we wish to define the molecular processes employed by symbiotic bacteria that mediate protection from disease.

There was a transient increase of FXN mRNA in peripheral blood mononuclear cells (PBMCs) 24 hours after dose, which is consistent with and confirms the results from the Phase 1 single ascending dose study. Based on current methods and procedures, the treatment effect of DT-216 on FXN protein was inconclusive due to high intra-individual variability, consistent with what was seen in the observational study. Study results showed that levels of endogenous FXN mRNA across individuals with FA, FA carriers and healthy individuals differed significantly. Additionally, levels in the interquartile range for FA patients did not overlap with FA carriers, which shows FXN mRNA levels between these two populations are distinct.

at No comments:

Generate your free logo online in minutes!

ai for logo design

Use the paid options to export it both in SVG (vector files) and high-resolution PNG. Renderforest Website Builder offers 100+ fully customizable website templates designed by professionals. Select a template and customize it without any technical skills.

ai for logo design

Ready-made templates

You can download the logos created with our logo maker as vector files and use them for many different purposes. Saving your logo designs as vector files makes it possible for you to scale up the icons without quality loss. There’s also the option to export your logo as a high-resolution PNG file. You need no design skills whatsoever to create the perfect logo for your brand. The interface of our online logo maker is intuitive and straightforward, making logo creation a fun and easy process. Tell our tool what you want, and it will generate the best logo design solution for your business.

AI Logo Maker Example

How does your product or service stand out from the competition? To get started on the endeavor of increasing brand recognition, you should first create a logo. A memorable logo design sticks in the minds of customers and reminds them of their previous encounters with your brand. Just like a professional human designer, we provide multiple logo formats and brand guidelines including all colors and fonts. Make sure people’s first encounters with your brand are positive, and half of your job is done. Either it sparks interest in potential customers and gets them to explore your brand, or it leaves them indifferent.

Is Renderforest Logo Maker free to use?

Turn to them for inspiration and come up with fresh ideas for your new logo. All the designs of the Renderforest Online Logo Maker are developed by skilled logo artists. Hence, the probability that you’ll end up with a poor result is very low. Whether you're a lover of modern or traditional style, you're sure to find something that suits your taste. Our icons strike a perfect balance between classic forms and the latest design trends.

Communicate the spirit of your brand and what it stands for with a concise visual statement. Discover a modern approach to branding with the our AI Logo Generator. Powered by sophisticated AI, we suggest logo ideas that resonate with your brand's core values. Elevate your identity with a blend of technology and artistry by entering a few words below. Our AI engine understands both logo data and design best practices in order to produce beautiful designs for your brand.

Custom logos in any style

Download the logo you've made with our online logo maker and turn it into a stunning animation with Renderforest Video Maker. Choose from colorful, dark, exploding, burning, 3D, footage-based, and other styles of intro and outro templates. There are many ways to make a logo design that expresses your brand’s unique identity. You can use the style, colors, and fonts of your logo in numerous creative ways to do so. Select your favorite logo style, whether it’s line art, solid, flat, watercolor, emblem, or minimal.

Is there online support available?

Browse through the suggested icons and pick the logo design you prefer. You can even preview it on different mockups to get an idea of how it will look in real life. Once you've made your choice, move forward to the editing section of the logo maker. Our logo maker is an online tool, meaning you can create a free logo design right from your browser. The two most recommended ones are Google Chrome and Safari. However, Mozilla and Internet Explorer are also well compatible with the website.

Best Free AI Logo Makers of 2023 - MarkTechPost

Best Free AI Logo Makers of 2023.

Posted: Tue, 30 May 2023 07:00:00 GMT [source]

There’s no need to spend hours communicating what you want to a designer or waiting for weeks for your new logo. With so many creative icons at your fingertips, the ideal design is only a few clicks away. Pick the one you like and feel free to customize your logo until it matches your needs.

Get started by diving into the vast library of our free logo creator and find some promising designs for your new logo. Pick the one you like and customize it to your heart’s desire. Enjoy the logo making process and get one step closer to building a solid brand. Instead of fixed templates, our logo maker can create new and unique designs for every customer. Explore the vast collection of ready-made templates available in the library of our logo maker. Use our icons with as little or as much customization as you’d like.

Enter your brand name, your tagline and provide a short description of your company or what you imagine your company logo to look like. Get free logo design suggestions and customize them at no cost. There’s a free download option that allows you to export your logo in low quality for non-profit use. However, to download your icon in high quality and use it for commercial purposes, you need to choose a paid option. Both the icons and fonts in our online logo creator are editable, enabling you to make a logo that’s uniquely your own.

This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. But if your customers cannot memorize your brand, the chances that they’ll buy from you again are quite low.

Or create your website from scratch with our simple yet comprehensive free editor. All the designs at Renderforest Logo Maker are created by specialized logo artists and graphic designers. Every icon has a unique and thoughtful design to give you the best results possible. A professional logo design communicates to customers that you take your brand seriously. It’s decisive in winning customers’ trust before they even get a chance to try out your products.

As customers grow familiar with your brand, they will start recognizing your products with ease.

If you are a small business trying to scale up, boosting your brand’s credibility is essential. Creating a business logo is the first step in this direction. The good news is, you can get a unique logo without breaking the bank using a free logo creator. A professionally designed logo differentiates you from competitors. It highlights your unique approach to solving customers’ needs and problems.

Don’t miss out on the chance to create a memorable logo design that withstands the test of time. Forget about the costly process of hiring designers or agencies. Renderforest Online Logo Maker is a tool that allows you to create stunning logo designs tailored to your business needs. Powered by artificial intelligence, it enables you to create your own logo without a designer’s help. Download your free logo design in low resolution or export it in high quality, choosing one of the paid options of our logo maker.

at No comments:

House Plans: Find Your Perfect House Plan

house blueprint

Blueprints can vary in complexity and can include everything from floor plans and elevations to electrical and plumbing schematics. Whether you’re looking to bring the California style to another region or looking to move to San Francisco and build a home, we have a plan for you. Check out our California style house plans and contact our support team with any questions.

Steps to Drawing a Professional House Blueprint

The event draws more than 25,000 guests each year and offers several dining spaces, including Roe Japanese Fusion, the Tudor Rose Bistro, and Wattle & Daub Tavern. The Shops at the Showcase offer an array of merchants, from handmade jewelry to artisanal chocolates, and are also home to the Shops’s Wine & Cheese Bar. The landmark mansion was built in 1902 by architect Joseph J. Blick for Gertrude Potter Daniels, who paid $15,000 for the shingle-style home.

Find the Perfect House Plans

Specifically, the rule will ensure adequate compensation for home care workers by requiring that at least 80 percent of Medicaid payments for home care services go to workers’ wages. Higher wages will likely reduce turnover, leading to higher quality of care for older adults and people with disabilities across the nation, as studies have shown. States will also be required to be more transparent in how much they pay for home care services and how they set those rates, increasing the accountability for home care providers. Finally, states will have to create a home care rate-setting advisory group made up of beneficiaries, home care workers and other key stakeholders to advise and consult on provider payment rates and direct compensation for direct care workers. A blueprint is an architectural plan of high resolution which includes site plans, layouts, elevations, and a variety of other elements or fixtures. Also, blueprint design covers general information such as projects types, colors, and material compositions of structural and decorative items.

Find the perfect house plan

Before, you could only handle blueprints in overly complicated CAD programs, but now a blueprint maker can handle this task. The intuitive and user-focused interface provides an easy design process without any tutorials or instructions. Take control of the blueprinting process - streamline your workflow, reduce costs, and ensure the successful completion of your projects. We do NOT sell or hijack your data, and you can keep using your Basic account for free as long as you want.

house blueprint

Alaska Senate panel approves state spending plan with smaller dividend than House proposed • Alaska Beacon - Alaska Beacon

Alaska Senate panel approves state spending plan with smaller dividend than House proposed • Alaska Beacon.

Posted: Fri, 26 Apr 2024 02:49:41 GMT [source]

Your neighbors might know about the history of your house or have a similar home. Planned and gated communities usually limit the available house styles, which means they used stock plans for that community. There's a good chance that the neighbor's home may have been designed by the same person or developer who built your home. Modern homes are virtually always built from detailed blueprints that serve as a roadmap for the building trade professionals laying foundations, erecting the structure, and finishing the house. For owners of older homes seeking to preserve or restore them in a historically accurate way, blueprints are an indispensable resource for remodeling and restoration work. All house plans and images on The House Designers® websites are protected under Federal and International Copyright Law.

Reading old advertisements can also give you a historical context for building processes of the past. Simple floor plans for your old house or similar ones may have been published in real estate advertisements. Go to your public library for back issues of local newspapers right before and around the time of the construction of your home. Farm journals and women's magazines also featured advertisements for building plans. Stock plans were also called catalog plans, stock building plans, stock house plans, mail-order plans, and pattern book houses. Stock plans were the blueprints for cookie-cutter homes, which reduced architectural design costs.

New Plans

White House Plan To Curb Drug Shortages Doesn't Address Generics' Quality - Forbes

White House Plan To Curb Drug Shortages Doesn't Address Generics' Quality.

Posted: Wed, 24 Apr 2024 12:03:34 GMT [source]

Any little nooks, like a pantry or ensuite, should be clearly labelled at this step.It’s important to assign room types (and not leave them as room 1, room 2, etc.) because it helps your client’s get a better understanding of the overall flow of the house. You will be able to visualize how to get from room to room using hallways, as well as how to access upper levels or basements using staircases. Most concrete block (CMU) homes have 2 x 4 or 2 x 6 exterior walls on the 2nd story. Regardless, Johnson said his “philosophy is you do the right thing and you let the chips fall where they may” and that he was “willing to take personal risk” for his job if it meant Congress could pass foreign aid. Designer Stephanie Hatten updated the Gatehouse Kitchen, turning it into an airy English-country-inspired space. An eye-catching natural stone by Walker Zanger was selected for the counters and backsplash, and the space was outfitted with the latest Monogram appliances.

With an intuitive interface, drag-and-drop functionality, and a variety of templates and tools, the RoomSketcher App makes it fast and easy to design, plan, and create your blueprints. Everyone deserves to be treated with dignity and respect and to have access to quality care. That’s why, today, Vice President Harris is announcing two landmark final rules that fulfill the President’s commitment to safety in care, improving access to long-term care and the quality of caregiving jobs.

Join Over 10 Million People Across the Globe

The designers worked with a color palette of Dunn-Edwards paints, and several chose to highlight the brand’s 2024 Color of the Year, a steely blue called Skipping Stones. Nods to Pasadena’s famous peacocks can be found throughout the designs, and many creators fearlessly brought in statement floors, enveloped their spaces with jewel tones, and added texture to ceilings. Others focused on bringing the beauty of the estate’s gardens and views inside with verdant murals, floral fabrics, and nature-inspired lighting.

A home's original blueprints feature dimensions, specs, and elevation drawings, showing where every window and door was originally placed. The house you're living in today may have begun in a much different style. Our online free tool brings thousands of objects to choose from and even more options for what you can draw without being a professional blueprint designer or the need to learn what dxf, svg, or obj formats mean. The added bonus is that all your projects are stored in the cloud and can be accessed from any device.

You should be able to produce a high-quality 2D Floor Plan complete with wall measurements and dimensions so it’s easy to translate your house plan into a house blueprint. We recommend starting on the RoomSketcher Floor Plan Gallery as there are lots of home design plans that can all be modified in the RoomSketcher App. Alternatively, you can find floor plans for houses on other websites, and order this plan from RoomSketcher illustrators. They will redraw this home design plan in the RoomSketcher App so you are able to modify it to suit your needs. If you choose this option, we recommend you find house plan examples online that are already drawn up with floor plan software. Browse these for inspiration, and once you find one you like, open the plan and adapt it to suit particular needs.

It provides lots of detail and layers which are essential for construction. This view shows the interior elements, such as cabinetry, sinks, toilets, and kitchen appliances. If you’re not sure what each symbol means, just refer to the tutorial, and you'll be able to remember them. Decorate it with more than a hundred pieces of furniture, wallpaper and floor coverings. Fast and easy to get high-quality 2D and 3D Floor Plans, complete with measurements, room names and more. We believe that a service like Floorplanner can and should be freely accessible in some sort of basic, useful form for everyone in the world, and we have been offering exactly that since 2007 with our Basic account.

Over seven million seniors and people with disabilities, alongside their families, rely on home and community-based services to provide for long-term care needs in their own homes and communities. This critical care is provided by a dedicated home care workforce, made up disproportionately by women of color, that often struggles to make ends meet due to low wages and few benefits. This rule will not only benefit residents and their families, it will also ensure that workers aren’t stretched too thin by having inadequate staff on site, which is currently a common reason for worker burnout and turnover. Workers who are on the frontlines interacting with residents and understanding their needs will also be given a voice in developing staffing plans for nursing homes.

Here is where you get to generate a HD visual of the blueprint.Using the HD visual tool, you can generate a rendering of the blueprint from a 3D view, eye-level view or bird’s eye view using custom viewpoints that can be saved for other projects. When adding the walls for a given room, Cedreo will automatically calculate the dimensions. The single-story home and its grounds have since been cleared and in its place will be a massive home in the modern farmhouse style that has come to dominate US suburbs. It was most recently home to the late Hilda Rolfe, the widow of Sam Rolfe, co-creator of the series The Man from Uncle. Video of the property from December 2022 shows a light-filled home that appears to have been well-preserved, with large windows, wood floors and mid-century furniture. Chris Pratt has drawn ire from architecture aficionados after news broke that the actor and his wife, Katherine Schwarzenegger, had razed a historic, mid-century modern home to make way for a sprawling 15,000-sq-ft mansion.

Cozy Stylish Chic Creative Director Jeanne K. Chung and designers Angela Lee and Caroline Meloche brightened the dark wood-paneled library to create a space where residents can unplug. “Our two main goals were to create a space that was comfortable and a little bit updated while also retaining that history and not touching or harming all the really cool features that were innate to the room and came with the house,” Meloche says. Wallpaper was added to the ceiling and the backs of the bookcases, and heavy wood blinds were replaced with soft draperies and Roman shades to make the space feel lighter.

Either start from scratch and draw up your plan in a floor plan design software. Or start with an existing house plan example and modify it to suit your needs. You can save a lot of time and money if you design a house plan yourself.

at No comments:

Homes for Sale, Real Estate & Property Listings

a house

I Am the Greatest is A House's most significant legacy, and is cited by many as one of the best ever released by an Irish band.[12] But it was followed by two more albums on Setanta. “You can go to a tract home and get a lot more square footage for the money than you could with a custom build. It’s a cookie-cutter home, and the quality may not be as good as a custom build, but building custom is harder today because the price of materials has skyrocketed,” Wing advises. The average homebuyer looks at at least 5 homes in 10 weeks before submitting an offer on a house.

Construction

What’s most exciting about this design renaissance, though, is the range of visions and styles represented around the city—due in part, perhaps, to the constant flow of new residents from around the country and world. Design scene is equally embracing of the primitive and the cutting-edge, the refined with the unrefined,” says Adam Blackman of Blackman Cruz, on Highland Avenue. Healy has also produced for Pony Club, and for other bands such as She's a Beauty. Bunbury continues as Couse's frequent musical collaborator and live accompanist.

What Does a Real Estate Agent Do? The Benefits of Hiring an Agent

A growing trend is the in-law suite, which is a unit built in or added onto a single-family home, typically meant for the parents (or in-laws) of the owners of the house. This can be located in the basement or elsewhere, but is physically part of the main house. This house type can be of any size (and many of the following types of houses are also single-family houses); the defining characteristic is its physical separateness (even if neighbors are nearby) from other residences. For residents who are envisioning the classic American dream of white picket fence and two-car garage, a single-family home is usually what comes to mind. Little is known about the earliest origin of the house and its interior; however, it can be traced back to the simplest form of shelters. "Since the Israel-Gaza war began, journalists have been paying the highest price — their lives — to defend our right to the truth. Each time a journalist dies or is injured, we lose a fragment of that truth," CPJ Program Director Carlos Martínez de la Serna said in a statement.

Albums

Footings are generally wider than the foundation itself and sit one foot below the frost line (the typical depth at which the soil freezes in your climate). Building a home is a huge project, and the average build will involve 22 subcontractors working on the home. At HomeLight, our vision is a world where every real estate transaction is simple, certain, and satisfying. The basic sheathing of the wall and roof surfaces concludes this stage, rendering the inside of the home weathertight.

Steps 8-14: Building the envelope

These can be built into the sides of hills and often have financial perks (they can be 20 to 30% less expensive than a typical home) and sustainability perks. A floating house on the other hand was never a functional water vessel and is instead a house built to be permanently moored. Cottages (in the old school sense of the word) and cabins are very similar according to some, but cabins typically evoke a more rustic, simplistic and one-with-nature feeling. Traditionally they were built of logs but this doesn’t always have to be the case. When purchasing a new house , the buyer has different legal protection than when buying other products.

Real estate resources

Architectural styles refers to historically derived house design categories, from Traditional to Modern. Also, be sure to click through to see even more subcategories for each house design style. For example, explore modern farmhouse plans, barndominium plans, one story farmhouse designs, modern one story layouts, and much more. In the early 20th century, some house designers started using prefabrication.

What Does It Mean to Rebuild After a House Fire? - The New York Times

What Does It Mean to Rebuild After a House Fire?.

Posted: Fri, 26 Apr 2024 09:00:31 GMT [source]

I Am the Greatest, new members and the Setanta years

Families of both men were in attendance as they have been at previous dinners. Spec and tract homes typically come with builder-grade cabinetry, which is the most basic (and affordable) type of cabinetry you can get that still looks good. Trim will be installed around the windows and doors, along the floor, and if you choose, around the ceiling, too (that’s called crown molding and can add a sophisticated look to any room). The average cost for fiberglass insulation is between $0.30 to $1.50 per square foot. With the sheathing attached to the bones of the house, the windows and doors can be installed. Tract homes are when a developer buys a large plot of land and divides that land into individual lots.

a house

Find Your Perfect House Plan

a house

More privacy is offered to the occupant as Pratt further claims, "the ordinary servants may never publicly appear in passing to and fro for their occasions there."[14] This social divide between rich and poor favored the physical integration of the corridor into housing by the 19th century. “There used to be a line about Los Angeles that everyone was either a screenwriter or an actor,” says Scotti Sitz, owner of L.A. “I think in some respects, you could start to make the case that everyone here is now an interior designer.” Indeed, the city’s design scene has boomed, with new shops and showrooms sprouting up every month.

The average cost of foam spray insulation is between $0.44 to $6.00 per square foot. The framing crew will erect lumber for the walls, flooring, ceiling, and roof trusses. Tiny houses have gained a lot of attraction in recent years, particularly due to their minimal financial requirements and low environmental impact. They can be built inexpensively and also to be eco-friendly and even have self-sustaining water or electric sources in some cases. To be considered a tiny house, the dwelling should be within 100 to 400 square feet and can be stationary or mobile. They’re not just backyard play structures; some people do choose to live in modern-day tree houses.

There are multiple types of floating residences and they each require specialty knowledge, so if you’re considering a floating home, it’s best to consult with an expert. Houseboats are typically boats that have been repurposed as full-time residences and though they may retain transportation capabilities, they are almost always moored semipermanently. They are an inexpensive type of home due to their simple design and mass production.

A House (Narrowly) Divided - AOL

A House (Narrowly) Divided.

Posted: Sat, 27 Apr 2024 13:00:00 GMT [source]

They’ll know what permits are necessary and they might already have a relationship with the municipality, which could help speed up the process. A custom home is where you have your own plot of land and hire a builder to build a house exactly the way you want it. Container homes can also be tiny homes, but this type of house is specifically made from existing containers (think cargo containers on a ship). They can be made from one large container or multiple smaller containers and can be configured in a variety of ways. There are specialty construction companies that focus on building container homes.

Couse now hosts a weekly radio music show on Irish national radio station, Today FM. The cover artwork was, as always, by Fergal Bunbury with an image by Irish photographer Amelia Stein,[11] and a second single from the album, "Take It Easy On Me" (1992), was also released. The Parlophone distribution of "Endless Art" was the flagship single from A House's new album, called I Am the Greatest (1991), Parolophone again taking over distribution from Setanta. Alongside new drummer Dawson, the recording introduced two other new members to the band, Susan Kavanagh, who had sung with a Dublin band named 'Giant',[10] and had been working on the TV show Jo Maxi, on backing vocals, and David Morrissey on keyboards.

In the United States, modern house construction techniques include light-frame construction (in areas with access to supplies of wood) and adobe or sometimes rammed-earth construction (in arid regions with scarce wood-resources). Some areas use brick almost exclusively, and quarried stone has long provided foundations and walls. To some extent, aluminum and steel have displaced some traditional building materials. Increasingly popular alternative construction materials include insulating concrete forms (foam forms filled with concrete), structural insulated panels (foam panels faced with oriented strand board or fiber cement), light-gauge steel, and steel framing.

at No comments:

Wednesday, April 3, 2024

SF Bay Sunset Cruise Private Charter & Public Sails

sunset cruise san francisco

How many times in your life do you get to watch the sun sink slowly into the Pacific, framed by the most famous bridge in the world? Add some loved ones and good friends, your favorite cocktail or a glass of local beer or wine and watch the sparkling skyline of San Francisco slowly come to life as day turns to night. It’s the recipe for an amazing experience and a memory you’ll carry for the rest of your days. While sunset cruises are available year-round, the best seasons are spring and fall when the skies are clearer, and the weather is more conducive to enjoying the outdoor views. However, San Francisco’s sunsets can be spectacular at any time of the year. Given the city’s famous microclimates, it’s wise to dress in layers for a sunset cruise.

Family Owned and Operated for over 130 years

After you finish dinner, you’ll want to stop by one of San Francisco’s famous comedy clubs. While not usually the first place that comes to mind when you think of stand-up comedy, the city has long been a fertile ground for the art — and these days, San Francisco is finally getting its due. A few great clubs you might want to check out include Cobb’s Comedy Club, The Setup San Francisco, Cheaper Than Therapy, Punch Line Comedy Club, and Best of SF Stand-Up Comedy. Our Best of Fisherman's Wharf Combo package combines three must-see attractions into one convenient, all-inclusive experience, saving you time and money while ensuring you see the best of what Fisherman's Wharf has to offer. Perfect for first-time visitors and seasoned visitors alike, this package guarantees a day of excitement, discovery, and unforgettable memories in San Francisco's most iconic neighborhood. Not to mention the most famous bridge in the world, and an equally infamous island prison.

sunset cruise san francisco

SF Bay Adventures

SF Bay Adventures offers our guests a variety of ways to catch amazing views from the vantage point of the water. Watch as the sunset become twilight to the west while the moon slowly rises in the east. If your tour is in the winter, you will see the sights of downtown San Francisco on your way to the beautiful Bay Bridge. Marvel at the bridge up close before heading back to Fisherman's Wharf. If your tour is in spring, summer or fall, you will pass the Marin Headlands, Sausalito, and Tiburon. Sail past Angel Island State Park and slowly circle the infamous Island of Alcatraz before returning to Fisherman's Wharf, after watching the sun set over the Pacific on this relaxing California cruise.

Opening hours

See the most iconic sights from the very special vantage of the water. No matter if you’re a born-and-bred Bay Area resident, or you’re just popping into town for a visit, it’s easy to have a fun time in San Francisco. Whether you’re checking out the natural beauty of the Bay and heading to Alcatraz Island, or stopping by the many delicious restaurants and bars the city has to offer, it’s a cinch to put together a “good-time” itinerary. That also holds true for a romantic night on the town — so we took the liberty of putting together a short list of some of our favorite things to do on date night! Below, we’ve highlighted a few potential attractions for visitors and locals alike to create a magical, unforgettable evening in San Francisco — and we show you how to cap it off with a gorgeous sunset view. Whether you’re looking for something the whole family can enjoy or a romantic evening out for two, your sail on Adventure Cat is sure to be a memorable highlight.

Evenings can be cool, especially on the water, so bring a jacket or shawl along with comfortable attire for an enjoyable experience. It’s a wonderful way for families to experience the beauty of San Francisco from the water, though it’s always good to check with the specific cruise for any age restrictions or child amenities. If you forgot to make reservations and can’t make it to a show — or if you’re just looking for a mellow, romantic way to spend an evening, there’s no better way to cap off a terrific time on the town than with an amazing sunset.

This S.F. company is partnering with the Giants for a new jersey logo - San Francisco Chronicle

This S.F. company is partnering with the Giants for a new jersey logo.

Posted: Thu, 03 Aug 2023 07:00:00 GMT [source]

Edgewater Marine

Entertainment varies by cruise but often includes music or live performances. But EVERYONE on our team is focused on giving you the best experience when you sail with us. So come aboard and create the best memories of your time in San Francisco.

Depart from the famed Fisherman's Wharf as you cruise past the San Francisco skyline. On this San Francisco Bay tour you'll enjoy the captain's commentary, live guitar music, and a delicious buffet of light, bite-sized appetizers. You'll see sights like North Beach Aquatic Park, Hyde Street Pier, the San Francisco Maritime National Park, and several others. You may even spot some seagulls, pelicans, and sea lions as you cruise along Fort Mason and the Marina District on your way to the massive Golden Gate Bridge. Unwind as you take in San Francisco's top attractions on this San Francisco sunset cruise.

Though San Francisco has a reputation for being foggy, you can still enjoy breathtaking sunset views from a litany of spots around town. There are plenty of incredible vantage points to watch the sunset in town, including Baker Beach, Bernal Heights Park, Grand View Park, Ocean Beach, Treasure Island, and many more. Share a few drinks with friends on this special sunset cruise – it's a fabulous way to finish a day of sightseeing. You'll see the city's natural and urban scenery from a whole new perspective. Our two-hour sunset cruise is the perfect way to cap off a day in San Francisco.

Bridge to Bridge Cruise

Sunset cruises in San Francisco usually last between 2 to 3 hours, providing ample time to enjoy the views, dining, and entertainment as the sun dips below the horizon. The cruises offer stunning views of iconic landmarks like the Golden Gate Bridge, Bay Bridge, and Alcatraz Island, especially during sunset. Nothing ends a great day in San Francisco as perfectly a watching the sunset on the Bay.

There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. She is one of the Bay’s most beloved yachts for locals and visitors alike. She is an eighty-foot sailboat built along the same lines as traditional tall-ships known for long, off-shore ocean passages in the 19th century. These types of schooners were designed for upright, comfortable and stable sailing.

Enjoy spectacular coastal views, a divine Pacific sunset, and a relaxing atmosphere as you sail past San Francisco landmarks like the Golden Gate Bridge, Alcatraz Island, and the Marin Headlands. Key sights include major landmarks and the city skyline, all bathed in the golden hues of sunset. This cruise is the perfect way to enjoy the breathtaking beauty of a west coast sunset with good friends, food, and drinks.

sunset cruise san francisco

Founded in 1892, the historic Red and White is legendary for its premiere San Francisco cruises. As a local, family owned business Red and White is committed to the environmental sustainability of San Francisco Bay and community education. Discover the most iconic sights of San Francisco on a hop-on, hop-off tour. Sit back and relax in the comfort of one of our open-top buses, as an entertaining audio guide tells you about the city’s unique history. Want to see the San Francisco Bay as the sun sets over the Pacific Ocean? Our 1.5-hour Sunset Sail is for those who want a serene, romantic experience.

Choose from a variety of ways to take a sunset cruise; Private Sail, Motor Yacht charter or a public sails. Popular options include an intimate private charter on the charming, all wood Grand Banks, Cimba. Or getting a fun group together and come aboard a classic tall ship like the Schooner Freda B.

at No comments:
Subscribe to: Posts (Atom)

Design Therapeutics Announces Positive Preclinical Data

Table Of Content A New Approach to Treating Genetic Disease Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 20...